Risk factors for healthcare-associated Clostridium difficile infection in pediatric hematopoietic stem cell transplant recipients
نویسندگان
چکیده
1305. External validation of predictive scores for mortality following Clostridium difficile infection Catherine Beauregard-Paultre, MD; Claire Nour Abou Chakra, PhD; Allison Mcgeer, MD, MSc; Annie-Claude Labbé, MD; Andrew E. Simor, MD, FRCPC, FACP; Wayne Gold, MD; Matthew P. Muller, MD, PhD, FRCPC; Jeff Powis, MD, MSc, FRCPC; Kevin Katz, MD, CM, MSc, FRCPC; Suzanne Cadarette, PhD; Jacques Pépin, MD; Julian R. Garneau, MSc and Louis Valiquette, MD, MSc, FRCPC; Microbiology and Infectious Disease, Université de Sherbrooke, Sherbrooke, QC, Canada, Infection Control, University of Toronto, Toronto, ON, Canada, Microbiology, CIUSSS de l’est-del’île-de-Montréal, Montreal, QC, Canada, Microbiology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, Toronto General Hospital, Toronto, ON, Canada, Medicine, St.Michael’s Hospital, Toronto, ON, Canada, Michael Garron Hospital, Toronto, ON, Canada, Department of Infection Control, North York General Hospital, Toronto, ON, Canada, University of Toronto, Toronto, ON, Canada, Centre de recherche du Centre hospitalier universitaire de Sherbrooke, Sherbrooke, QC, Canada
منابع مشابه
Risk factors for recurrent Clostridium difficile infection in hematopoietic stem cell transplant recipients.
BACKGROUND Recurrent Clostridium difficile infection (CDI) represents a significant burden on the healthcare system and is associated with poor outcomes in hematopoietic stem cell transplant (HSCT) patients. Data are limited evaluating recurrence rates and risk factors for recurrence in HSCT patients. METHODS HSCT patients who developed CDI between January 2010 and December 2012 were divided ...
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Patients undergoing solid organ and stem cell transplantation are at increased risk of Clostridium difficile infection (CDI) compared with nontransplant patients. CDI may be associated with significant morbidity in this population including prolonged hospitalization, increased hospital charges, and complications in the transplanted organ. A combination of host factors, including both B-cell and...
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Antibiotic use continues to be the most important risk factor for the development of Clostridium difficile infection (CDI) through disruption of the indigenous microbiota of the colon. This factor, together with environmental contamination, makes hospital and other healthcare facilities the perfect breeding ground for the infection. Several groups of patients are exposed to the hospital environ...
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Background. Clostridium difficile is the leading cause of infectious diarrhea among hospitalized patients and is a major concern for patients undergoing hematopoietic stem cell transplantation (HSCT). Risk factors and the natural history of C. difficile infection (CDI) are poorly understood in this population. Methods. We performed a retrospective nested case-control study to describe the epide...
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Clostridium difficile infection (CDI) is frequently diagnosed in recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT). We characterized early-transplant CDI and its associations, and analyzed serially-collected feces to determine intestinal carriage of toxigenic C. difficile. Fecal specimens were collected longitudinally from 94 patients during allo-HSCT hospitalization,...
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